Ask the Expert: 7 Common Medications for Fibromyalgia Pain


Tramadol also increases the action of two neurotransmitters: serotonin and norepinephrine. It’s similar to antidepressants in that way. These two mechanisms work together to change your perception of pain.

6. Opioid analgesics

Opioid analgesics, also called narcotics, are a class of pain relievers. These include morphine (MS Contin) and oxycodone (OxyContin).

Opioids can be helpful when there is severe fibromyalgia pain. However, their use for pain management of this condition is controversial. They are highly addictive and should only be used when other medications are not effective. Additionally, opioid analgesics don’t address the musculoskeletal problems associated with fibromyalgia.

common medications for fibromyalgia

7. Non-steroidal anti-inflammatory drugs (NSAIDs)

Non-steroidal anti-inflammatory drugs (NSAIDs) are effective for relief of pain caused by inflammation. Fibromyalgia is not caused by inflammation. However, the use is of NSAIDs to relieve fibromyalgia pain is prevalent.

NSAIDs such as ibuprofen and aspirin are not effective in treating symptoms of fibromyalgia when used alone. But they may reduce pain when used in conjunction with another fibromyalgia medication.

These drugs can cause stomach irritation and should be taken with food. Their use in large doses or over long periods of time should be closely monitored.

common medications for fibromyalgia

The bottom line 

Your fibromyalgia treatment plan usually requires a combined approach. Some patients do not respond to a single drug. Your doctor may prescribe combination therapy to get you maximum pain relief.

The aim of your fibromyalgia treatment is to relieve pain symptoms in the most effective way. This may differ from person to person. Your health care team will choose the best option for you. Before starting any medication:

  • discuss it with your doctor
  • be open and honest about your concerns
  • ask questions
  • be sure to talk about any other medications you are taking

What are your experiences with common medications for fibromyalgia pain?

Tell us about your pain journey in the comments. 

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Updated in February 2019 with new information and resources


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